Impella® 2.5 and 5.0

Powerful Support, Femoral Approach
With the Impella® 2.5 and Impella® 5.0, support of the left ventricle without a thoracotomy is now possible.

The catheters are inserted via the femoral artery and advanced with the help of a guide wire into the left ventricle. The Impella® 2.5 is implanted percutaneously via an introducer. The Impella® 5.0 is implanted via a small cut-down of the femoral artery.

The Impella® 2.5 - Innovation in the Field of Cardiology

The Impella® 2.5 is a minimally invasive ventricular unloading catheter, which is inserted percutaneously via the femoral artery. Up to 2.5 liters of blood per minute are delivered by the pump from the left ventricle into the ascending aorta, providing the heart with active support in extremely critical situations. A large percentage of patients with acute myocardial infarction require a temporary mechanical support system in order to survive. The Impella® 2.5 is the system of choice because it can be inserted quickly and easily, and provides extremely efficient cardiovascular support. The Impella® 2.5 is CE certified for up to 5 days use.

The Impella® 2.5 is a minimally invasive percutaneous ventricular unloading catheter that allows the heart to rest and recover by:

• actively unloading the ventricle
• reducing myocardial workload and oxygen consumption, while increasing cardiac output, coronary and end-organ perfusion.

Percutaneous insertion allows rapid positioning into the left ventricle where up to 2.5 liters of blood per minute is then pumped from the left ventricle into the ascending aorta - actively unloading the heart and reducing oxygen demand..

Only 4 mm in diameter (12 Fr), it nevertheless delivers up to 2.5 liters of blood per minute.

Pump miniaturization and outstanding delivery rates were developed on the basis of Impella's platform technology. To date, the Impella® 2.5 has been implanted more than 600 times, mainly in European centers.

Impella® 5.0 - peripheral support

The Impella® 5.0 is a variant of the directly inserted Impella® LD (see surgical Impellas). It is not placed surgically like the LD, but rather via a peripheral blood vessel such as the femoral artery, in order to provide the heart with left ventricular support. This means that the pump system can be implanted without opening the thorax (thoracotomy). In particular, those patients for whom revascularization with thoracotomy is not indicated benefit from this system - for example patients with acute myocardial inflammation or acute myocardial infarction (acute heart attack). This pump system can also be used after bypass surgery, if the patient necessitates mechanical cardiovascular support.

Indications for Impella® LP2.5 & Impella® LP5.0

• Acute myocardial infarction
• Cardiogenic shock
• Low output syndrome
• High risk PTCA
• Post PCI
• Bridge to next decision
  

Advantages of Impella® 2.5 & Impella® 5.0

• World's smallest cardiovascular support system, fully implantable and minimally invasive
• Extremely small synthetic surfaces - minimal hemodilution (anticoagulation)
• Quick and easy insertion, Impella® LP2.5 even percutaneously
• Active cardiovascular support (Impella® 2.5 - 2.5 liters of blood per minute; Impella® 5.0 - 5 liters of blood per minute)
• Cardiac support can be adjusted according to patient needs
• Increase of cardiac output, coronary and end-organ perfusion
• Reduction of myocardial workload and oxygen consumption
• Minimal procurement costs

Impella® System Advantages

• System can be used for right ventricular, left ventricular or biventricular cardiovascular support
• World's smallest cardiovascular support system - fully implantable and minimally invasive
• Extremely small synthetic surfaces - minimal hemodilution (anticoagulation)
• Quick and easy to implant
• Minimal procurement costs
• Cardiac support can be adjusted according to patient needs
• High flow rate (up to 5 liters)
• Increase of cardiac output, coronary and end-organ perfusion
• Reduction of myocardial workload and oxygen consumption
  

Reducing Infarction Size

Early implantation of the Impella® System may result in regeneration of the heart, and can provide protection against multiple organ injury resulting from inadequate perfusion.

The fact that infarction size can be reduced by up to 70% through early implantation of the Impella® system has been unequivocally substantiated in an animal study.

The Impella® System

The Impella® system consists of the

• Impella® Mobile Console
• Impella® Power Supply
• Purge system (Impella® purger shown)
• Cart (not shown)

The Impella® Mobile Console is at the heart of the overall system.

The Impella® Mobile Console

The Impella® System cable coming from the patient is connected to a portable control panel with dimensions of approximately 30 x 30 cm and weighing only 3 kg: called the Impella® Mobile Console. The Impella® Mobile Console is extremely compact and handy, thus, transport within the clinic (e.g. from the operating room or the cath lab to intensive care), as well as transfer to other heart centers by ambulance or helicopter are made easy. The control panel can be operated with rechargeable batteries for at least one hour at full power and the mains power supply provides power for continuous use. Data logging is possible for the entire period of use. Stored data can be subsequently queried with special software via laptop or PC.

The Impella® Mobile Console is laid out for mono-ventricular support. Any Impella® System, regardless of whether left or right ventricular support is provided, can be operated with the control panel. Quick and easy handling of the Impella® Mobile Console is assured, in particular by means of user-friendly software. Thanks to its simplicity, and not least due to its very low price, the Impella pump system also provides smaller clinics with the opportunity of using mechanical cardiovascular support systems for the first time.

Purge Systems:

Impella® purger

The Impella® purger continuously rinses the Impella pumps. A glucose solution (20%) is drawn into a 50 ml syringe along with heparin (2500 I.U.). The pump delivery rate can be precision adjusted, allowing for ideal adaptation to actual needs.

Infusomat® P

Alternately, Impella® systems are fitted with the Infusomat® P from        B Braun. Here the solution is delivered via bags instead of syringes. Please contact Abiomed Europe for further details.